Overview
Human Cerebral Blood Flow Regulation
Status:
Recruiting
Recruiting
Trial end date:
2026-05-01
2026-05-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study tests basic differences in how men and women control brain (cerebral) blood flow (CBF), at rest and under stress. The stress is low oxygen or high carbon dioxide. The investigators hypothesize that sex differences per se, plus sex hormone differences, drive different signals in blood vessels that change the way CBF is regulated. The investigators will test these mechanisms with medicine infusions during stress, and measure CBF using state-of-the-art MRI approaches. Research confounding variables like aging and disease will be mitigated by comparing younger adults (18-40 years old).Phase:
Early Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
University of Wisconsin, MadisonCollaborator:
National Heart, Lung, and Blood Institute (NHLBI)Treatments:
Estradiol
Ganirelix
Ketorolac
Ketorolac Tromethamine
Methyltestosterone
Testosterone
Testosterone 17 beta-cypionate
Testosterone enanthate
Testosterone undecanoate
Criteria
Inclusion Criteria:- All participants will be healthy adults between 18-40 years old, matched for age and
aerobic fitness
- Participants will be non-hypertensive (<125/80mm Hg)
- Participants will be non-obese (BMI 19-25 kg/m2)
- Participants will have normal blood glucose (<100 g/dl)
- Participants will have normal lipids (LDL cholesterol <130 mg/dl, triglycerides <150
mg/dl)
- Women must have a natural regular menstrual cycle
Exclusion Criteria:
- Participants with a history of:
- peripheral vascular disease
- hepatic disease
- renal disease
- hematologic disease
- stroke
- obesity
- prediabetes
- diabetes
- sleep apnea
- Participants with current BP>130/85 mmHg
- Regular smokers
- Taking cardiovascular medications
- Women who take hormonal birth control
- Women who are pregnant or have polycystic ovarian syndrome [Hormonal birth control
will not be allowed in women]