Overview

How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
0
Participant gender:
All
Summary
To determine whether one glaucoma eye drop is less likely to cause changes to the surface of the eye (conjunctiva) than another. The two different prostaglandins are Xalatan and Travatan Z.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Wills Eye
Collaborator:
Pfizer
Treatments:
Latanoprost
Ophthalmic Solutions
Travoprost
Criteria
Inclusion Criteria:

- Age 21 or older

- Able to understand protocol and agree to 3 visits

- Any type of glaucoma

- Selective laser trabeculoplasty, Argon laser trabeculoplasty, peripheral iridotomy
accepted

- Naïve: No prior glaucoma treatment (medical or surgical)

- If patient non-compliant, must be off meds 3 months

- Xalatan: At least one month use

Exclusion Criteria:

- Both Groups: Any history of ocular surface disease

- Dry eye syndrome or prior Restasis use

- Prior ocular surgery other than cataract extractions

- Uveitis or other inflammatory disease of the eye or adnexa

- Systemic medications that might influence ocular inflammation

- Any active inflammation or infection

- Pregnancy or intention to become pregnant

- Naïve: Prior use of topical glaucoma medication unless off for 3 months.

- Use of preserved artificial tear preparations in last 30 days and more than one year
history of chronic use

- Xalatan: Prior use of Travatan or Travatan Z