Hormone Therapy Plus Chemotherapy in Treating Patients With Prostate Cancer
Status:
Completed
Trial end date:
2005-02-04
Target enrollment:
Participant gender:
Summary
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as
luteinizing hormone-releasing hormone agonist, flutamide, and bicalutamide may stop the
adrenal glands from producing androgens. Drugs used in chemotherapy work in different ways to
stop tumor cells from dividing so they stop growing or die. Combining hormone therapy with
chemotherapy may kill more tumor cells. It is not yet known whether chemotherapy given at the
same time as hormone therapy is more effective than chemotherapy given after hormone therapy
in treating prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy given at the
same time as hormone therapy with that of chemotherapy given after hormone therapy in
treating patients who have prostate cancer.
Phase:
Phase 3
Details
Lead Sponsor:
Radiation Therapy Oncology Group
Collaborators:
Cancer and Leukemia Group B Eastern Cooperative Oncology Group National Cancer Institute (NCI) NRG Oncology Southwest Oncology Group