Overview

Hormone Replacement Therapy and Anti-HIV Drugs in HIV-Infected, Postmenopausal Women

Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of this study is to find out if the anti-HIV drugs nelfinavir (NFV), lopinavir/ritonavir (LPV/r), and efavirenz (EFV) change the amount of estrogen in the blood when taken along with hormone replacement therapy (HRT) for menopause. HRT can be helpful for treating bothersome symptoms of menopause. However, it is not routinely used in HIV-infected postmenopausal women because it is not known how HRT interacts with anti-HIV drugs. The information obtained from this study will help doctors make recommendations for HRT in postmenopausal HIV-infected women.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Efavirenz
Estradiol
Estradiol 17 beta-cypionate
Estradiol 3-benzoate
Estradiol valerate
Hormones
Lopinavir
Medroxyprogesterone
Medroxyprogesterone Acetate
Polyestradiol phosphate
Ritonavir
Criteria
Inclusion Criteria

Patients may be eligible for this study if they:

- Are postmenopausal women over 18 years old.

- Are infected with HIV.

- Have a CD4 cell count of 100 cells/mm3 or greater within 45 days prior to study entry.

- Have a plasma viral load less than 55,000 copies/ml within 45 days prior to study
entry.

- Are willing to comply with study requirements. These include not changing smoking
habits during the course of the study and not consuming caffeine or alcohol prior to
PK sampling.

- Have had a Pap smear within 12 months prior to study entry.

- Meet one of the following requirements: a) patients must currently be on stable PI or
EFV regimens plus 2 or more acceptable NRTIs, or b) patients must not currently be
taking any ARVs, with the exception of an NRTI-only regimen.

- Have a way to obtain their ARVs outside of the study and agree to continue their ARV
regimen for at least 12 weeks of the study.

Exclusion Criteria

Patients may not be eligible for this study if they:

- Have had breast or endometrial cancer, thrombophlebitis, or thromboembolism.

- Have had serious nausea, vomiting, or abdominal pain within 30 days prior to study
entry.

- Have had a serious illness requiring systemic treatment and/or hospitalization within
14 days prior to study entry.

- Are allergic or sensitive to the drugs that will be used for HRT.

- Have undiagnosed postmenopausal bleeding.

- Have coronary artery disease.

- Have used hormonal therapies within 8 weeks prior to study entry.

- Have used DMPA (Depo Provera) within 180 days prior to study entry.

- Have used the anti-HIV drugs ZDV and d4T at the same time within 30 days prior to
study entry.

- Have used other medications specified in the protocol within 30 days prior to study
entry.

- Are using experimental drugs without the written approval of the study co-chairs.

- Are unable to adhere to the ARV or HRT medications while on study, in the opinion of
the investigator.