Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia
Status:
Withdrawn
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
There have been reports in the medical literature demonstrating a link between the
development of provoked vestibulodynia (PVD), a sexual pain disorder, and hormonal
contraceptive (HC) use. The purpose of this pilot study is to assess the prevalence of HCs
induced PVD among a HC naïve population, to evaluate which of the components of the HCs are
associated with a higher risk of the development of PVD, and to evaluate which clinical and
genetic factors predispose the patient to HCs induced PVD. Assessments will be made through
patient questionnaires, physical examinations, and blood tests. Microarray techniques will be
employed to characterize, on a global level, the gene expression profiles of women who
develop PVD in comparison to those who do not develop PVD. Patients will be followed for a
year. Results will be used to develop a larger clinical trial.