Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function

• Status: Terminated
• Trial end date: 2020-10-15
• Target enrollment: 0
• Participant gender: All

Summary

Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal. Cigarettes, cigars, medicinal nicotine, and e-cigarettes all acutely impair brachial artery endothelial function (flow-mediated dilation, FMD). Also, cigarettes cause both acute and chronic impairment in coronary endothelial function, but the comparative effects of hookah are unknown. Hookah tobacco is heated with burning charcoal. So, the smoke contains "tar" and nicotine plus charcoal combustion products. These include carbon monoxide (CO) and proatherogenic oxidants (especially carbon-rich nanoparticles) that the study team expected to impair endothelial function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Collaborators: National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH)
• Treatments: Ascorbic Acid; Carbon Monoxide; Charcoal; Tadalafil; Vitamins

Criteria

Inclusion Criteria:

• 21-25 y/o hookah smokers: smoked hookah > 12 times in the last 12 months.

• 21-25 y/o cigarette smokers: smoked >100 cigarettes and smoked in the last 30 days.

• 35-49 y/o hookah smokers: smoke hookah at least once per week for > 20 years.

• 35-49 y/o cigarette smokers: have > 20 pack-year cigarette smoking history.

• All subjects must have:

• no history of illicit drug use or marijuana.

• no evidence of cardiopulmonary disease by history or physical.

• no diabetes with fasting blood glucose <100 mg/dl.

• BP<140/90 mmHg.

• resting heart rate<100 bpm.

• BMI<30kg•m2.

• no prescription medication.

• normal EKG and echocardiogram.

Exclusion Criteria:

• suboptimal echocardiographic window.

• exhaled CO>10 ppm (smoking non-abstinence).

• positive pregnancy test.

• psychiatric illness.

• other conditions deemed unsafe to participate.