Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
Status:
Terminated
Trial end date:
2020-10-15
Target enrollment:
Participant gender:
Summary
Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to
prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to
bear the same warning labels as cigarettes. But there is little scientific evidence to
substantiate this proposal. Cigarettes, cigars, medicinal nicotine, and e-cigarettes all
acutely impair brachial artery endothelial function (flow-mediated dilation, FMD). Also,
cigarettes cause both acute and chronic impairment in coronary endothelial function, but the
comparative effects of hookah are unknown. Hookah tobacco is heated with burning charcoal.
So, the smoke contains "tar" and nicotine plus charcoal combustion products. These include
carbon monoxide (CO) and proatherogenic oxidants (especially carbon-rich nanoparticles) that
the study team expected to impair endothelial function.
Phase:
Phase 1
Details
Lead Sponsor:
Cedars-Sinai Medical Center
Collaborators:
National Institute on Drug Abuse (NIDA) National Institutes of Health (NIH)