Overview

Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

Status:
SUSPENDED
Trial end date:
2025-09-01
Target enrollment:
Participant gender:
Summary
To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV). Primary Outcomes: * Residual gastric volume that precludes adequate endoscopic examination * Residual gastric volume that necessitates premature termination of the endoscopy procedure * Need for endotracheal intubation due to stomach contents. * Occurrence of aspiration events requiring extended observation/monitoring, unplanned therapeutics, and/or hospital admission Secondary Outcomes: * Presence of any solid food * Presence of moderate liquid content * Increased RGV(Residual Gastric Volume) defined as any amount of solid content or \> 0.8 mL/Kg of fluid content (measured from the aspiration/suction canister). * Differences in primary and secondary outcomes between different medications
Phase:
PHASE4
Details
Lead Sponsor:
The Cleveland Clinic
Treatments:
dulaglutide
Liraglutide
semaglutide
Tirzepatide