High-flow Oxygen Therapy During Exercise in Idiopathic Pulmonary Fibrosis
Status:
Completed
Trial end date:
2021-03-30
Target enrollment:
Participant gender:
Summary
Objectives:
1. To evaluate endurance time during cardiopulmonary exercise test (CPET) performance
comparing standard oxygen therapy to high-flow nasal cannula (HFNC) oxygen therapy in
subjects with idiopathic pulmonary fibrosis (IPF) with exertional desaturation.
2. To assess oxygenation level (peripheral and muscular) as well as dyspnea and fatigue
during exercise in IPF subjects with exertional desaturation using oxygen
supplementation with HFNC compared with standard oxygen supplementation.
Method: multicenter crossover clinical trial. Patients with IPF presenting oxygen
desaturation during the six-minute walking test (6MWT) (SpO2 mean ≤ 85%) will be included
consecutively . Each subject evaluated will perform initially an incremental CPET to evaluate
the patient's maximum exercise capacity. Supplemental oxygen will be applied to maintain SpO2
>85% with a Venturi mask. Maximum exercise capacity and the appropriate final oxygen
inspiratory fraction (FiO2) needed for the following tests will be determined.
Posteriorly each patient will perform two constant load CPET (at 75% of the maximum workload
achieved with the incremental CPET); one with standard oxygen therapy and the other one with
HFNC oxygen therapy. Endurance time, dyspnea and leg fatigue and oxygen saturation
(peripheral and muscular) will be recorded.
Evaluation measures: Endurance time, dyspnea and leg fatigue (Borg scale), and oxygen
saturation.