High-dose Prednisone in Duchenne Muscular Dystrophy
Status:
Completed
Trial end date:
2008-02-01
Target enrollment:
Participant gender:
Summary
This study will help to determine whether a high-dose weekly course of prednisone therapy is
safer than and at least as effective as daily dose therapy for people with Duchenne muscular
dystrophy (DMD). Boys who are enrolled in this study should not have taken carnitine, other
amino acids, creatine, glutamine, Coenzyme Q10 or any herbal medicines within the last three
months. There will be a two-visit screening to take place in one week to ensure a
reproducible manual muscle test. The subject will then be randomized and put into either the
daily or weekly regimen. The duration of the study is twelve 28-day treatment cycles
(approximately 12 months) with follow-up visits at month one, three and then every three
months.
Phase:
Phase 3
Details
Lead Sponsor:
Cooperative International Neuromuscular Research Group