High-dose Ibuprofen for Patent Ductus Arteriosus (PDA) in Preterm Infant
Status:
Completed
Trial end date:
2010-10-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesized that the early treatment of PDA with ibuprofen doses higher
than those actually recommended might increase the closure rate in preterm infants with
gestational age <29 weeks without increasing the occurrence of associated adverse effects. To
assess this hypothesis the investigators planned a multicenter randomized controlled study to
compare the effectiveness of the current ibuprofen regimen to that of a high-dose regimen in
closing PDA.