High Dose Vitamin A Compound in Treating Participants With Resectable Non-Small Cell Lung Cancer

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial studies how well high dose vitamin A compound works in treating participants with non-small cell lung cancer that can be removed by surgery. Vitamin A compound may increase the number of germinal centers (immune centers that make antibodies mature) in tumor and lymph tissues which may be beneficial to patients with cancer.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Collaborator: National Cancer Institute (NCI)
• Treatments: Anti-Infective Agents; Corticosterone; Fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether; Retinol palmitate; Vitamin A; Vitamins

Criteria

Inclusion Criteria:

• Patient must be 18 years of age or older.

• Patients must have either biopsy proven or radiographically suspected non-small cell lung cancer.

• Patients must have disease in the chest that is felt to be surgically resectable.

• ECOG performance status of 0-2.

• Ability to understand and the willingness to sign an IRB-approved informed consent document

Exclusion Criteria:

• Patients younger than 18 years of age

• Women who are pregnant or breast feeding.

• Patients may not be receiving any other investigational agents for the treatment of nonsmall cell lung cancer.

• Patients may not be taking the following medications: high dose vitamin A supplement (multivitamin supplements prohibited only if vitamin A content is greater than 3,500 international units), bexarotene, alitretinoin, tretinoin, adapalene, isotretinoin, acitretin, doxycycline, minocycline, or demeclocycline,

• Uncontrolled intercurrent illness including, but not limited to, pancreatitis, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

• Hypervitaminosis A - toxic effects of ingesting too much vitamin A.