High Dose Versus Standard Dose Proton Pump Inhibitor (PPI) in High-risk Bleeding Peptic Ulcers After Combined Endoscopic Treatment

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study was designed to evaluate the efficacy an adjuvant use of standard dose or high dose of proton pump inhibitor after combined endoscopic hemostasis therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Pantoprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• adults aged above 16 years old with acute nonvariceal upper gastrointestinal bleeding

• read, agree to attend the study, and signed informed consent indicated to receive esophagogastroduodenoscopy(EGD)

• peptic ulcers with high risk lesions (active bleeding: spurting, oozing peptic ulcers. Ulcers with NBVV: nonbleeding visible vessel)

Exclusion Criteria:

• unable to receive EGD (unable to open mouth, upper gastrointestinal obstruction)

• bleeding tendency (platelet < 50x109/L, prothrombin time INR >2, ongoing use of heparin or coumadin)

• gastric malignancy

• myocardial infarction within recent one week

• recent cerebrovascular event within recent one week

• pregnancy

• refuse to attend the study

• known allergy history to epinephrine or pantoprazole