High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals
Status:
Completed
Trial end date:
2017-01-12
Target enrollment:
Participant gender:
Summary
Cryptococcal meningitis (CM) is an infection of the membranes covering the brain and spinal
cord, caused by the fungus Cryptococcus neoformans. CM most often affects people with
compromised immune systems, like those with advanced HIV infection. This study explored the
safety, tolerability, and therapeutic effect of a new treatment regimen with high-dose
fluconazole for management of CM in HIV-infected patients.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Amphotericin B Amphotericin B, deoxycholate drug combination Deoxycholic Acid Fluconazole Liposomal amphotericin B