High Dose Dexamethasone Vs. Conventional Dose Prednisolone in Adult ITP

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the long term effects of pulse high dose dexamethasone and conventional dose prednisolone in treatment of adult patients with ITP.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cooperative Study Group A for Hematology
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria :

• a true thrombocytopenia on blood smear

• adequate megakaryopoiesis on bone marrow examination

• the absence of clinically apparent associated conditions or cause of thrombocytopenia

• Age over 16 years

• A platelet count of less than 30x109/L

Exclusion criteria :

• previous treatment for ITP.

• other causes of thrombocytopenia such as HIV infection, lymphproliferative disease, liver disease, or definite SLE.

• Patients with life threatening bleeding and pregnant women should be excluded.