High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid
Status:
Active, not recruiting
Trial end date:
2025-03-01
Target enrollment:
Participant gender:
Summary
The prevalence of analgesics opioids addiction in chronic pain patient is very difficult to
know. Many studies indicated that the prevalence of addiction varied from 0% up to 50% in
chronic non cancer pain patients, and from 0% up to 7.7% in cancer pain patients. Analgesics
opioids use have increasingly been increased in chronic pain for 20 years. However, a long
use, at least 3 months in this type of pain has not proved a large efficiency and we have
noticed a habituation, tolerance and withdrawal when treatment was decreased or stopped. In
current practice, patients with chronic pain, often keep their analgesics opioids despite the
absence of pain relief and benefits in quality of life.
Nowadays, no withdrawal strategy is the reference in chronic non-cancer pain patients with
physical opioid dependence. The most common clinical strategy is progressive decrease of
analgesic opioid. But this strategy is often a failure in these patients (no data are
available in literature).
It's necessary to make a prospective pilot study to assess benefits from this practice.
The primary objective of this study is to assess a new ambulatory withdrawal strategy,
consisting of a temporary opioid rotation with buprenorphine in CNCP patients suffering from
physical withdrawal symptoms and who have failed a conventional strategy of progressive
withdrawal from their opioid analgesic treatment.
Phase:
Phase 2
Details
Lead Sponsor:
University Hospital, Clermont-Ferrand
Treatments:
Analgesics Analgesics, Opioid Buprenorphine Buprenorphine, Naloxone Drug Combination Naloxone