High (100IU/Kg) Versus Standard (50IU/Kg) Heparin Dose for Prevention of Forearm Artery Occlusion
Status:
Completed
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
This is a prospective, multi-center, superiority study of parallel design. Patients are
enrolled if they are older than 18 years old, are scheduled for 5 or 6 Fr diagnostic coronary
angiography and the interventional cardiologist is willing to proceed with radial access.
Patients are randomized before diagnostic catheterization to receive intravenously either
100IU/Kg or 50 IU/Kg of unfractionated heparin (UFH) in a 1:1 ratio. Patients are discharged
usually within 4 to 6 hours after coronary angiography.
Radial artery in each patient is evaluated either in-hospital or during a subsequent visit by
one physician who is blinded to the actual antithrombotic treatment given. Radial artery is
considered occluded if it exhibits ultrasonographically no antegrade flow signal both at
baseline and after reevaluation on a second occasion, within 30 days after the index
procedure. Initially patent arteries will not be reexamined and are thought to remain
permanently patent. The investigators also monitor major bleeding (defined as ≥ 5g/dL
decrease in hemoglobin or ≥15% decrease in hematocrit or any life-threatening bleeding
(confirmed by MRI or computed tomography) and large local hematomas of the forearm (defined
as those extending beyond the forearm).