To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV)
ulcerations of the corneal epithelium prevents progression to the blinding complications of
stromal keratitis and iridocyclitis.
To determine the efficacy of low-dose oral acyclovir in preventing recurrent HSV eye
infection in patients with previous episodes of herpetic eye disease.
To determine the role of external factors (such as ultraviolet light or corneal trauma) and
behavioral factors (such as life stress) on the induction of ocular recurrences of HSV eye
infections and disease.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Eye Institute (NEI)
Treatments:
Acyclovir
Criteria
Protocol-specific criteria are noted in the description above.