Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs

• Status: Unknown status
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study was to investigate a possible response to nalbuphine (Nubian) and morphine with traditional Chinese herbs in healthy volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tri-Service General Hospital
• Treatments: Morphine; Nalbuphine

Criteria

Inclusion Criteria:

• Normal healthy adult subjects between 20-40 years of age

• Body weight within 80-120% of ideal body weight

• Acceptable medical history, physical examination and clinical laboratory determinations

Exclusion Criteria:

• Recent history of drug or alcohol addiction or abuse

• Donating greater than 150 ml of blood within two months prior to Period I

• Taking any prescription medication or any nonprescription medication within 14 days prior to Period I doing

• Receiving any investigational drug within 30 days prior to Period I dosing

• Taking any drug known to induce or inhibit hepatic drug metabolism within 30 days prior to the beginning of the study

• Any clinically significant diseases

• History of allergic response to nalbuphine or related drugs and traditional Chinese herbs