Hepatic artery infusion (HAI) with oxaliplatin (OX), systemic 5 fluorouracil (5FU), and
leucovorin (HAI/OX/FU) will be implemented using an interventional radiology technique to
obviate the need for initial major surgery (catheter placement) in patients who have
unresectable liver metastasis from colorectal cancer. The study goal is to reduce tumor size
to make possible a complete resection of all lesions. Secondary goals are to reduce or
eliminate the complexity usually associated with HAI, to accomplish most or all of the
treatment as an outpatient, to reduce costs, and to avoid the hepatotoxicity associated with
HAI/floxuridine (FUDR). Oxaliplatin has been selected because of its ease of use, known
toxicology, and established efficacy in colorectal cancer.