Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The optimal heparin regimen during cardiopulmonary bypass (CPB) has not been well established
in obese patients.
Results of a preview study show that the standard heparin management based on total body
weight in obese patients during CPB resulted in excessive heparin level, which could lead to
excessive postoperative bleeding.
To avoid this overdosing, an initial heparin bolus based on ideal body weight in obese
patients was proposed.
The main objective of the study is to evaluate the effects of heparin injection, based on
ideal body weight, on intraoperative plasma heparin levels and activated coagulation time
(ACT) in a population of obese patients, compared to a group of obese patients undergoing CPB
surgery with heparin management based of total body weight.
The secondary objectives are to evaluate the relationship between heparin level and ACT in
each group of patients and at different time points during CPB, and to compare the incidence
of bleeding, intraoperative transfusions and complications in the two groups of patients.