Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

Cervical conization is done for pre-cancer disease. The procedure is performed with local anesthesia and general anesthesia. Local anesthesia is given by paracervical block, and several different local anesthetics is being used including bupivacaine with and without adrenaline. Adrenaline might reduce local bleeding and reduce toxicity of bupivacaine by reducing absorption, but might affect cardiovascular function. This study will examine this effect.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helse Fonna
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Racepinephrine

Criteria

Inclusion Criteria:

• Clinical diagnosis of cervical pre-cancer

Exclusion Criteria:

• Pregnancy

• Feeding mother

• Bad nutritional state

• Infection

• Treatment for hypertension

• Diabetes for many years or complications

• Cardiovascular disease

• Serious anemia

• Cardial arrythmia

• Serious liver-disease

• Hypersensitivity to local anesthesia of amide-type