Hemodynamic Effects of Vasopressin in Early Septic Shock Stage
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Vasopressin is a vasopressor used in patients with septic shock. However, its systemic
hemodynamic effects and its microcirculation effects are not completely known and understood.
This study aimed to evaluate the effect of exogenous vasopressin on sublingual
microcirculation using the sidestream dark field technique and to correlate it with its
systemic effects. To this prospective interventional study, patients with septic shock were
included during the first 48 hours of use of catecholamine vasopressors, admitted to the
intensive care unit of a university hospital. Vasopressin was administered at 0.04 U / min
for one hour. Systemic hemodynamic measurements were obtained immediately before and 1 hour
after vasopressin. In addition, images of sublingual microcirculation were collected through
sidestream dark field technology. Further analysis with specific software was done after.
Phase:
N/A
Details
Lead Sponsor:
Federal University of São Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo