Hemodynamic Effects of Dexmedetomidine in Septic Shock
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
The current treatment regimen of patients with septic shock requires a sufficient hemodynamic
support aiming to preserve tissue oxygen requirements and perfusion. Therefore, aggressive
fluid challenge and vasopressor agents play a pivotal role. To increase total peripheral
resistance and preserve organ perfusion, a continuous infusion of catecholamines is often
needed. Because sepsis is usually associated with adrenergic receptor and post-receptor
abnormalities, the efficacy of such treatment regimens often gradually decreases over time,
thereby complicating hemodynamic support. Experimental evidence suggest that α-2 agonists
increase pressor responsiveness following lipopolysaccharide administration. This study will
assess the effects of the sedation with dexmedetomidine (α-2 agonist) on norepinephrine
requirements in patients with septic shock.