Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes
that may impact patient outcomes.
Changes from baseline in cardiac output and other hemodynamic variables following induction
of anesthesia and knee-chest positioning were compared. Propofol plasma concentrations were
also measured after induction of anesthesia and after the knee-chest position.
The aim of this study was to assess whether planned reductions in target-controlled infusion
propofol concentrations attenuate the hemodynamic changes associated with anesthesia
induction and knee-chest position.
The secondary aim was to quantify the variation in propofol measured plasma concentrations
(Cm), both after induction and after KC positioning, and correlate them with predicted
concentrations (Cp) by the Schnider Pk model.