Hematopoietic Stem Cell Transplant in Devic's Disease
Status:
Completed
Trial end date:
2018-11-01
Target enrollment:
Participant gender:
Summary
This study is designed to examine whether treating Devic's disease patients with high dose
cyclophosphamide together with rabbit antithymocyte globulin (rATG)/rituximab (drugs which
reduce the function of the immune system), followed by return of previously collected
patient's stem cells will result in improvement in Devic's disease. Stem cells are
undeveloped cells that have the capacity to grow into mature blood cells, which normally
circulate in the blood stream. The purpose of the intense chemotherapy is to destroy the
cells in patient's immune system, which may be causing his/her disease. The purpose of the
stem cell infusion is to produce a normal immune system that will no longer attack patient's
body. The purpose of study is to examine the safety and efficacy of this treatment. The drugs
used in this study treatment are drugs for commonly used for immune suppression.