Overview

Hematopoietic Stem Cell Transplant for Sickle Cell Disease

Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
This is a phase I/II study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem cell transplants. Doctors will give patients a new drug (fludarabine) to see if this drug changes patients immune system and reduces the patient's cells (host) from rejecting donor cells (graft) after the patient gets a Hematopoietic (blood) stem cell transplant.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Case Comprehensive Cancer Center
Treatments:
Fludarabine
Fludarabine phosphate
Vidarabine