Hematopoietic Cell Transplantation for Pediatric Patients With Hematologic Malignancies
Status:
Completed
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
This is a phase II trial of reduced intensity conditioning with Bu/Flu/ATG in pediatric
patients with hematologic malignancies at high risk for transplant related mortality with
standard transplantation. Patients qualify based on organ system dysfunction, active but
stable infection, history of previous transplant or late stage disease. We plan to enroll 45
patients through the Pediatric Blood and Marrow Transplant Consortium (PBMTC) and anticipate
that the outcome of the trial will pave the way for phase II or III disease specific
protocols addressing efficacy of the approach compared to standard transplant approaches in
better risk patients.