Helicobacter Pylori and Lacidophilin Tablets in Combination With Vonorazan Dual Therapy
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Our previous study included 119 Helicobacter pylori(H. pylori)-infected Chinese patients
without previous eradication history who were randomized to low-or high-dose
amoxicillin-vonoprazan regimens consisting of amoxicillin 1 gram either b.i.d. or t.i.d plus
vonoprazan 20 mg b.i.d for 7 or 10 days. Neither 7-or 10-day VA dual therapy with either
b.i.d. or t.i.d. amoxicillin achieved satisfied efficacy (i.e., <90%) when given as
first-line treatment for H. pylori infection. Lacidophilin tablets have been reported to
increase the eradication rate of H. pylori while reducing the incidence of adverse
effects.This study evaluated the efficacy and safety of lacidophilin tablets in combination
with amoxicillin-vonoprazan dual therapy for 10 days as first-line treatment for H. pylori in
China.
Phase:
Phase 4
Details
Lead Sponsor:
The First Affiliated Hospital of Nanchang University