Helicobacter Pylori Eradication With Probiotics Combined With Triple Therapy Versus Bismuth-containing Quadruple Therapy
Status:
Completed
Trial end date:
2020-12-05
Target enrollment:
Participant gender:
Summary
This study aims at evaluating efficacy and safety of probiotics combined with triple therapy
(Clostridium butyricum capsule and Bacillus coagulans tablets, esomeprazole, clarithromycin
and amoxicillin) versus bismuth-containing quadruple therapy
(bismuth,esomeprazole,clarithromycin and amoxicillin) in H. pylori eradication. It is
hypothesized that probiotics combined with triple therapy is non-inferior to
bismuth-containing quadruple therapy. Patients with confirmed H. pylori positive status will
be randomized to one of the treatments described above. At week 2 and 6 follow-up visits, a
urea breath test(UBT) will be performed to confirm eradication.