Overview

Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas

Status:
Completed
Trial end date:
2018-02-17
Target enrollment:
0
Participant gender:
All
Summary
This is an open-label, single arm, multi-center, Phase II trial to evaluate the progression free survival in patients with metastatic adenocarcinoma of the pancreas treated with a hedgehog inhibitor (GDC-0449) in combination with chemotherapy (gemcitabine and nab-Paclitaxel).
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborators:
Celgene Corporation
Genentech, Inc.
Stand Up To Cancer
Treatments:
Albumin-Bound Paclitaxel
Gemcitabine
Paclitaxel
Pancrelipase
Criteria
Inclusion Criteria:

1. Patient has histologically or cytologically confirmed metastatic adenocarcinoma of the
pancreas. Patients with islet cells tumors are excluded. Biopsy within 14 days of
starting treatment.

2. Patient has measurable disease, defined as at least one lesion that can be accurately
measured in at least one dimension (longest diameter to be recorded) as >20 mm with
conventional techniques or as >10 mm with spiral CT scan.

3. Patient has NOT received previous radiotherapy, surgery or chemotherapy or
investigational drug therapy for the treatment of metastatic disease. If the patient
received radiotherapy, chemotherapy or investigational therapy in the adjuvant setting
it should be completed 3 weeks prior to enrollment. If a patient received gemcitabine
in the adjuvant setting, tumor recurrence must have occurred at least six months after
completing the last dose of gemcitabine

4. Age >18 years.

5. Life expectancy of greater than 1 month.

6. ECOG performance status 0 or 1 (Karnofsky >70%).

7. Patients must have adequate organ and marrow function

Exclusion Criteria:

1. Patient had received chemotherapy or radiotherapy for metastatic disease

2. Patient is receiving other investigational agents.

3. Patient has known brain metastases, unless previously treated and well controlled for
at least three months (defined as clinically stable, no edema, no steroids and stable
in 2 scans at least 4 weeks apart)

4. History of allergic reactions attributed to compounds of similar chemical or biologic
composition to GDC-0449 or other agents used in the study.

5. Patients taking medications with narrow therapeutic indices that are metabolized by
cytochrome P450 (CYP450), including warfarin sodium (Coumadin®) are ineligible.

6. Uncontrolled illness including, but not limited to, ongoing or active infection
requiring IV antibiotics, symptomatic congestive heart failure not controlled with
medication, unstable angina pectoris, cardiac arrhythmia, or psychiatric
illness/social situations that would limit compliance with study requirements.

7. Pregnant women are excluded

8. Patient has undergone a major surgery, other than diagnostic surgery (i.e. surgery
done to obtain a biopsy for diagnosis without removal of an organ) within four weeks
prior to Day 1 of treatment on this study.

9. History of other disease, metabolic dysfunction, physical examination finding, or
clinical laboratory finding giving reasonable suspicion of a disease or condition that
contraindicates use of an investigational drug or that might affect interpretation of
the results of the study or render the patient at high risk from treatment
complications