Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology
Status:
Recruiting
Trial end date:
2027-10-01
Target enrollment:
Participant gender:
Summary
Background:
Gastric cancer is a common and serious cancer. Standard treatment is chemotherapy drugs.
Researchers want to see if a new treatment helps. It is surgical removal of the cancer and
heated chemotherapy delivered to the abdominal cavity called HIPEC.
Objective:
To test if surgical removal of tumors plus heated intraperitoneal chemotherapy can improve
survival in people with gastric cancers.
Eligibility:
People ages 18 and older with gastric cancer who can have most tumors surgically removed
Design:
Participants will be screened with:
- Medical history
- Physical exam
- Blood, urine, and heart tests
- Scans
- Tissue sample from previous surgery
- Endoscopy with biopsy: A tube with a camera goes through the mouth and into the stomach.
It and takes a sample of stomach tissue. Participants might may get medicine to make
them drowsy.
- Laparoscopy: Small cuts are made in the abdomen. A thin tube with a light and camera is
inserted into the abdomen. Participants sleep through the procedure.
Participants will stay in the hospital. They will have:
- Surgery to remove as many tumors as possible.
- HIPEC for 60 minutes: Two thin tubes are put into the abdomen. Two chemotherapy drugs
are given through one tube. They are drained out through another at a temperature a few
degrees above normal body temperature. Another drug is given in a vein.
Recovery for 7-21 days: Participants will have tubes in their stomach and bladder and IVs for
a few days. They will get pain medicine, IV fluids, antibiotics, and blood transfusions as
needed.
Participants will have visits every few months for 3 years, then one a year. Visits include
physical exam, blood tests, and scans. They also include dietary assessment and questions.