Heart Rate Variability in Response to Metformin Challenge
Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
Diseases caused by brain energy supply defects can be innate (fibromyalgia secondary to
familial mitochondrial disorders) or acquired (tardive dyskinesia or weight gain associated
with prolonged antipsychotic use). Patients with these possible mitochondrial disorders will
provide a baseline resting heart rate sample, ingest low-dose metformin (500 mg), and then
provide an additional sample 2 hours later.