Heamodynamic Effects of Paracetamol in Septic Shock Patients
Status:
Completed
Trial end date:
2023-01-24
Target enrollment:
Participant gender:
Summary
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic
abnormalities that are associated with a greater risk of mortality than sepsis alone.
Clinically, this includes patients who fulfill the criteria for sepsis who, despite adequate
fluid resuscitation, require vasopressors to maintain a mean arterial pressure ≥65 mmHg and
have a lactate >2 mmol/L (>18 mg/dL). Feve is a common sign of infection in septic shock
critically ill patients. Many critically ill patients experience pain. Paracetamol is
considered safe and currently one of the most common antipyretics and used as part of
multimodal analgesia for acute pain in the intensive care unit. According to the company's
product information leaflet, the rate of hypotension complicating intravenous paracetamol
treatment ranges from 0.01 to 0.1%. However, recent studies reported a much higher incidence
and may be harmful in critically ill adults. The hemodynamic effects of intravenous (IV)
paracetamol are unknown in septic shock patients, that the most vulnerable population and
hemodynamically unstable.
The aim of this study is to assess the incidence of hypotension of the extended intravenous
paracetamol (acetaminophen) infusion over three hours in comparing with intravenous
paracetamol bolus over 15 minutes in hemodynamically unstable patients (septic shock).