Head-to-head Comparison of Diagnosis Value of Keloid on 68Ga- FAPI-04 and 68Ga-RGD PET-CT

• Status: Recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Keloid scars are common benign fibroproliferative reticular dermal lesions. Fibroblasts are considered to be the key cellular mediators of fibrogenesis in keloid scars. The αvβ3 integrin is a key mediator of angiogenesis and thus may be an important diagnostic and therapeutic target associated with active keloid development processes. Thus this prospective study is going to investigate whether 68Ga-FAPI PET/CT and/or 68Ga-RGD PET/CT may provide evidence for diagnosis and evaluate the effectiveness of treatment.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Treatments: Glycine

Criteria

Inclusion Criteria:

• suspected or confirmed pulmonary fibrosis patients;

• signed written consent.

Exclusion Criteria:

• pregnancy;

• breastfeeding;

• known allergy against FAPI or RGD

• any medical condition that in the opinion of the investigator may significantly interfere with study compliance