Overview

Head and Neck Cancer Study Project in the Geriatric Population

Status:
NOT_YET_RECRUITING
Trial end date:
2027-06-01
Target enrollment:
Participant gender:
Summary
This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a novel reduced intensity regimen. The regimen will be tailored based on the programmed cell death ligand 1 combined positive score (PD-L1 CPS) and will involve 4 cycles of systemic chemotherapy and/or immunotherapy followed by radiation treatment.
Phase:
PHASE3
Details
Lead Sponsor:
Brown University
Collaborators:
Rhode Island Hospital
The Miriam Hospital
Treatments:
Cetuximab
Paclitaxel
pembrolizumab
Radiotherapy