Haloperidol vs. Valproate in Agitation

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the efficacy of haloperidol and valproate in management of people with agitation in emergency department

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University of Medical Sciences
• Treatments: Haloperidol; Haloperidol decanoate; Valproic Acid

Criteria

Inclusion Criteria:

• Clinical diagnosis of psychomotor agitation

• aged 18 to 65 years

Exclusion Criteria:

• Pregnant patients

• Severe liver disease

• History of drug (haloperidol/valproate) allergy

• Readily amendable causes for the agitation (hypoxemia or hypoglycemia)

• Hypotension (systolic blood pressure (SBP) ≤ 90 mm Hg)

• Known history of liver disease or uncontrolled diabetes

• Noticeable or suspected head trauma

• Previous history of neuroleptic malignant syndrome

• Receiving psychotropic medication, neuroleptic agents or cholinesterase inhibitors at the time of enrollment