Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Will the use of prophylactic Haloperidol for patients undergoing open heart surgery reduce the incidence, duration, and severity of post cardiotomy delirium?

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: McMaster University
• Treatments: Haloperidol; Haloperidol decanoate

Criteria

Inclusion Criteria:

• Greater than or equal to 70 years of age, undergoing a median sternotomy OR 60-69yrs of age with one or more of the risk factors:

• TIA/Stroke;

• Euroscore greater than or equal to 5;

• abnormal clock draw.

Exclusion Criteria:

• Parkinsonism,

• on any antipsychotic medications pre-op,

• active delirium,

• emergent surgery,

• Haloperidol allergy,

• schizophrenia,

• prolonged QTc.