HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss
Status:
Withdrawn
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points
towards endometriosis and progesterone resistance as an underlying cause of uRPL. Previous
non-RCT studies have suggested the luteal hCG provides a useful treatment for uRPL. We
propose performing a randomized controlled trial to compare mid-luteal hCG with oral
progesterone to prevent early pregnancy losses. the endpoint will be ongoing pregnancy and
live birth rates. Equal numbers of patients will be randomized to each group.