HIV Drug Switch Followed by HCV Therapy in HIV-HCV Co-Infection
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
This is an prospective open label pilot study conducted over 32 weeks.
A total of 25 eligible participants who are infected with HCV and HIV will be recruited from
2 Canadian HIV Trials Network (CTN) sites (Ottawa Hospital Research Institute and McGill
University Health Centre)
This study is looking into the effectiveness of a combination of
Elvitegravir/Cobicistat/Emtricitabine/ Tenofovir Alafenamide Single Tablet Regimen (E/C/F/TAF
STR) for HIV treatment and Harvoni for HCV treatment .
This study will assess the effect that the study drug has on the metabolism of sugar, the
changes in fat in the bloodstream and other metabolic changes. Metabolism is the process your
body uses to get or make energy from the food you eat.
This study may provide information on the impact of liver fibrosis (scarring of liver
tissues) on metabolic changes before, during and after HCV antiviral therapy.
Drug-drug interactions (DDI) DDI between E/C/F/TAF and LPV-SOF have been well evaluated and
no clinically significant interactions have been identified.
A switch to E/C/F/TAF in the context of LPV-SOF HCV antiviral treatment preparation may be
particularly beneficial because of its:
1. favorable side effect profile
2. once daily STR formulation
3. known DDI profile with LPV-SOF
4. neutral effect on liver fibrosis
5. improved kidney and bone safety profile with the use of TAF
Conduct of this study is justified as it:
1. Assesses a minimal pill count and dosing frequency strategy of co-treatment of HIV and
HCV using well tolerated medications with an excellent safety profile and known DDI
profile.
2. Provides additional safety data for TAF in the HIV-HCV co-infected population.
3. Quantifies adherence and identifies obstacles to full adherence in this population.
There is a paucity of data related to DAA adherence in licensing studies.
4. Provides real-world safety and efficacy data to support the public funding for LPV-SOF
DAA therapy in HIV-HCV co-infected populations.
5. Provides preliminary data on the immunologic and metabolic consequences of HCV clearance
in HIV-HCV co-infection
6. As a pilot study, the information gathered will inform the feasibility of future
clinical trials evaluating novel treatment strategies for HIV-HCV co-infected patients.
Phase:
Phase 3
Details
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborators:
CIHR Canadian HIV Trials Network Gilead Sciences
Treatments:
Antiviral Agents Cobicistat Emtricitabine Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Ledipasvir Ledipasvir, sofosbuvir drug combination Rilpivirine Sofosbuvir Tenofovir