HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial
Status:
Not yet recruiting
Trial end date:
2020-08-24
Target enrollment:
Participant gender:
Summary
This is a double-blinded, randomized placebo-controlled trial to determine if pre-exposure
prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily, for health
care workers in the hospital reduces symptomatic and asymptomatic COVID-19 disease during the
pandemic. 374 health care workers will be randomized at a 1:1 allocation between the
intervention and placebo arms and followed for 90 days. The cumulative incidence of COVID-19
infection in the intervention group will be compared to the cumulative incidence of COVID-19
in the placebo group with relative (risk ratio and 95% CI) and absolute measures (risk
difference and 95% CI).