HDAC Inhibitor Valproic Acid as an Effective Therapy for Chronic Lymphocytic Leukemia
Status:
Terminated
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES
To investigate:
- the mechanism of Valproic Acid (VPA)-induced apoptosis in B-CLL
- the ability of VPA in combination with standard chemotherapy or new antitumor agents to
induce a synergistic antitumor effect in chronic lymphocytic leukemia (CLL) cells
- the clinical efficacy of VPA in previously treated CLL patients.
This will be an example of a translational research study where the results of our laboratory
studies will be applied to a clinical trial in the CLL clinic at CancerCare Manitoba.