HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitair Ziekenhuis Brussel
• Treatments: Chorionic Gonadotropin

Criteria

Inclusion Criteria:

• age ≤ 36 years,

• regular menstrual cycles,

• body mass index (BMI) between 18 and 29 kg/m²,

• basal levels of FSH (≤ 12 IU/l),

• estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle).

• The use of donor sperm was also accepted as inclusion criteria.

Exclusion Criteria:

• PCOS

• endometriosis