HBPL Study of the Impact of the NK1 Antagonist Aprepitant
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
The proposed research will focus on investigating the determinants and consequences of CAD
via measurement of physiological, behavioral and subjective effects of physiologic and
psychologic stress cues in CAD volunteers in the laboratory, and through examination of the
effects of the effects of Aprepitant, an NK1 antagonist, on the above effects. This study
will examine the effects of the above stress cues on cocaine and alcohol craving under acute
Aprepitant dosing, and under placebo conditions. The study is a within-subjects crossover
design using 24 subjects.