GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG
Status:
Not yet recruiting
Trial end date:
2026-08-01
Target enrollment:
Participant gender:
Summary
Post-transplantation cyclophosphamide (PTCY) has become increasingly popular in the
haploidentical HCT setting because it overcomes the HLA-mismatch barrier and levels GVHD
risk. This advantage may also prove useful in the context of unrelated donor (UD)
transplantation. GVHD prophylaxis for matched unrelated donor hematopoietic cell
transplantation (alloHCT) in Europe is mainly conducted with ATG. Still, the burden of acute
and chronic GVHD and especially of relapse remains high with both approaches for GVHD
prevention.
PTCY has not been tested against the current standard ATG for GvHD prophylaxis in large
randomized trials. The goal of this trial is to compare the outcomes of PTCY and ATG for
patients receiving unrelated donor PBSCT. PTCY-based prophylaxis promises to have beneficial
net effects on immune reconstitution, GVHD and disease control, and thus might impact on
patient survival.