Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Inflammatory bowel disease (IBD) is a chronic, debilitating, relapsing inflammatory disorder
affecting the gastrointestinal tract which does not have a medical cure. IBD consists of 2
different forms: Crohn's Disease (CD) and Ulcerative Colitis (UC). In the last 2 decades, Gut
Microbial Transplantation (GMT), also known as fecal transplantation, has been used as a
treatment option for Clostridium difficile colitis and UC. The literature supports strong
evidence for the plausibility of using GMT for patients with IBD associated colitis,
especially for patients with UC.
This research will be conducted in the Helen DeVos Children's Hospital (HDVCH) Pediatric
gastrointestinal outpatient clinic. A pilot study of ten patients will be conducted to
evaluate if GMT improves clinical symptoms in patients with IBD. Patients with IBD colitis
(UC and CD with colonic involvement only) will be approached for GMT as a treatment option
for their disease. Each subject will undergo 5 sessions (1 session/day, and not necessarily
on consecutive days) of GMT within a period of 10 days. Post treatment evaluation will be
done at their regularly scheduled clinic follow up.
Healthy donors >18 years of age will be chosen by the family, inclusive of immediate family
members and friends. Donors will be required to complete a screening questionnaire, provide
medical history, and undergo blood and stool tests.