Gut Decontamination In Pediatric Allogeneic Hematopoietic
Status:
Active, not recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
This research study is for participants who are undergoing allogeneic hematopoietic stem cell
transplantation (HSCT) and are at risk for developing acute graft-versus-host disease (GVHD).
GVHD is a complication of HSCT in which immune cells from the donor cause inflammation and
injury to tissues and organs of the HSCT recipient. Vancomycin-polymyxin B (commonly called
"vancopoly") is an oral antibiotic that is given to people undergoing allogeneic HSCT as a
preventive measure for acute GVHD. This research study is studying the effects of vancopoly
on the microorganisms living in the intestine during and after stem cell transplantation.