Gut Butyrate and Blood Pressure in African Americans
Status:
Active, not recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
African Americans have the greatest burden of hypertension. Recently, the short-chain fatty
acid, butyrate, has been reported to have some effect on blood pressure. Butyrate is not
normally ingested since it is made by bacteria in the gut as a byproduct of fiber
fermentation. In this proof of concept study, the investigators will investigate the effect
of butyrate absorbed in the gut (via the participant self-administering an enema with
butyrate) has on blood pressure.
Phase:
Phase 1
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborators:
North Carolina Agriculture & Technical State University North Carolina Translational and Clinical Sciences Institute