Guidance Model of Standardized Treatment of Antidepressants in Bipolar Disorder
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
The bipolar depression patients of 18-55 years old were recruited. At the time of enrollment,
the demographic, symptomatic, neuropsychological, neurobiological and genetic data was
collected. After the completion of the baseline assessment and examination, the patients were
given lithium carbonate or lithium carbonate combined with SSRI antidepressant treatment.
Clinical evaluation was performed at 2 and 8 weeks after treatment, including the therapeutic
efficacy and adverse drug reactions, and monitoring of serum lithium concentration. The
patients further receive the fMRI scans after treatment for 8 weeks. Through above work, this
study aimed to provide some guidance for the use of antidepressants in patients with bipolar
depression.