Overview

Guanfacine for PONV and Pain After Sinus Surgery

Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
0
Participant gender:
All
Summary
Postoperative nausea and vomiting (PONV) and pain are the most common causes of Post Anesthesia Care Unit (PACU) discharge delay, with untreated PONV occurring in 20-30% of post-surgical patients. The effect of guanfacine (GF) administration on pain and nausea scores will be assessed with two groups. One group will receive 1 mg of GF to take orally and the other group will receive a similar appearing placebo (containing no drug) to take orally.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Vanderbilt University
Vanderbilt University Medical Center
Treatments:
Guanfacine
Criteria
Inclusion Criteria:

- VUMC patients undergoing sinus surgery in MCE OR

Exclusion Criteria:

- Inability to read and freely consent

- Patients who take alpha-2 agonists routinely (guanfacine, clonidine, tizanidine)

- Patients undergoing sinus surgery planned for greater than 3 hours

- Patients with significant pre-existing pain, on chronic pain (opioid, methadone)
therapy, severe fibromyalgia or other pre-existing pain condition in any body part

- Patients with preoperative nausea/vomiting at baseline.

- Pregnant or lactating women