Several drugs have been proposed for ALS. These drugs included: Topiramate, Lamotrigine,
creatine, Vit. E, Pentoxifylline, etc. Although most of the trials showed a positive trend,
none of them reached a statistically significant result. The only exception is the Riluzole
trial, that demonstrated a small but significant reduction in mortality between treated and
untreated patients. Aim of our study is to determine if the add-on of GH to treatment with
Riluzole is able to reduce neuronal loss in the motor cortex of ALS patients.
Phase:
Phase 2
Details
Lead Sponsor:
Federico II University
Collaborators:
Agenzia Italiana del Farmaco Istituto Biostrutture e Immagini, CNR Naples